Acetyl-(Ala11·15)-Endothelin-1 (6-21)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BQ-3020 是一种内皮素受体 (endothelin receptor) (ETBreceptor) 激动剂，取代[125I]ET-1 与猪小脑 ETB 受体结合，IC50 值为 0.2 nM。BQ-3020 引起兔肺动脉血管收缩和猪膀胱颈松弛，可用于心血管疾病研究。

BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.

BQ-3020 (3 mg/kg 皮下注射, 单次给药) 可使癌痛小鼠模型在注射后 3 小时内的癌痛减轻约 50%。Animal Model:Cancer pain mouse model Dosage:3 mg/kg Administration:Injected subcutaneously at the site of the greatest tumor development Result:Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection

BQ-3020（0.01–300 nM，7分钟）对 PhE 预收缩的尿路上皮剥离组织产生浓度依赖性松弛。BQ-3020 (0.01–200 nM，20 min) 通过抑制 ETB 受体引起兔肺动脉剂量依赖性血管收缩，其 EC50 值为 0.57 nM。

———

Others

Other Targets

ETB: 0.2 nM (IC50)

———

———

143113-45-5

1989.36

C96H139N20O24S

>98% (HPLC)

———

———

———

(-20℃)

With Ice Pack

≥ 2 years